Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer

An adequate level of arginine in the tissue microenvironment is essential for T cell activity and survival. Arginine levels are regulated by the arginine-catabolizing enzyme, arginase (ARG). It has been reported that arginase II (ARG2), one of two ARGs, is aberrantly expressed in prostate cancer cel...

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Bibliographic Details
Main Authors: Ino, Yoshinori, Yamazaki-Itoh, Rie, Oguro, Seiji, Shimada, Kazuaki, Kosuge, Tomoo, Zavada, Jan, Kanai, Yae, Hiraoka, Nobuyoshi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570471/
https://ncbi.nlm.nih.gov/pubmed/23424623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055146
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