Development and validation of a HPLC-MS/MS method with electrospray ionization for quantitation of potassium oxonate in human plasma: Application to a pharmacokinetic study

A rapid, sensitive and specific HPLC-MS/MS method was developed and validated for the quantification of potassium oxonate (Oxo) in human plasma using [(13)C(2),(15)N(3)]-Oxo as an internal standard (IS). The target substance was separated from human plasma using the solid-phase extraction method. Ch...

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Main Authors: HAO, GUANGTAO, BAI, SHAOBO, LIANG, HAIXIA, LIANG, YUGUANG, QU, HENGYAN, GAO, HONGZHI, LI, YUANYUAN, ZHENG, ZHUANJIE, WANG, XIAOFANG, LIU, ZEYUAN
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570248/
https://ncbi.nlm.nih.gov/pubmed/23407381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2013.908
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