Cholesterol feeding of mice expressing cholesterol 7α-hydroxylase increases bile acid pool size despite decreased enzyme activity

Dietary cholesterol regulation of cholesterol 7α-hydroxylase (Cyp7a1), the rate-limiting enzyme in the classical pathway of bile acid synthesis, has been implicated in plasma cholesterol responsiveness. In the current study, the effects of 0.0% and 0.5% cholesterol diets were examined in Cyp7a1 knoc...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Tiemann, Michaela, Han, Zhihua, Soccio, Raymond, Bollineni, Jaya, Shefer, Sarah, Sehayek, Ephraim, Breslow, Jan L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC357015/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14762172/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308426100
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