A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1

Dysregulation of microRNAs is a common feature in human cancers, including breast cancer (BC). Here we describe the epigenetic regulation of miR-148a and miR-152 and their impact on BC cells. Due to the hypermethylation of CpG island, the expression levels of both miR-148a and miR-152 (miR-148a/152)...

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Hlavní autoři: Xu, Qing, Jiang, Yue, Yin, Yu, Li, Qi, He, Jun, Jing, Yi, Qi, Yan-Ting, Xu, Qian, Li, Wei, Lu, Bo, Peiper, Stephen S., Jiang, Bing-Hua, Liu, Ling-Zhi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570052/
https://ncbi.nlm.nih.gov/pubmed/22935141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjs049
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