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Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission

Carbon monoxide (CO) synthesized by heme oxygenase 2 (HO2) and nitric oxide (NO) produced by neuronal NO synthase (nNOS) mediate nonadrenergic/noncholinergic (NANC) intestinal relaxation. In many areas of the gastrointestinal tract, NO and CO function as coneurotransmitters. In the internal anal sph...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Watkins, Crystal C., Boehning, Darren, Kaplin, Adam I., Rao, Mahil, Ferris, Christopher D., Snyder, Solomon H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC357001/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14983060/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308695100
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