Selectivity profiling of the novel EP(2) receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP(2) receptor

BACKGROUND AND PURPOSE: Understanding the role of the EP(2) receptor has been hampered by the lack of a selective antagonist. Recently, a selective EP(2) receptor antagonist, PF-04418948, has been discovered. The aim of this study was to demonstrate the selectivity profile of PF-04418948 for the EP(...

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Detalhes bibliográficos
Main Authors: Birrell, Mark A, Maher, Sarah A, Buckley, James, Dale, Nicole, Bonvini, Sara, Raemdonck, Kristof, Pullen, Nick, Giembycz, Mark A, Belvisi, Maria G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570009/
https://ncbi.nlm.nih.gov/pubmed/22747912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02088.x
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