RNF4 is required for DNA double-strand break repair in vivo

Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signaling and repair proteins to the sites of DNA lesions. Coordinated protein SUMOylation and ubiquitylation have crucial...

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Bibliographic Details
Main Authors:	Vyas, R, Kumar, R, Clermont, F, Helfricht, A, Kalev, P, Sotiropoulou, P, Hendriks, I A, Radaelli, E, Hochepied, T, Blanpain, C, Sablina, A, van Attikum, H, Olsen, J V, Jochemsen, A G, Vertegaal, A C O, Marine, J-C
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2013
Subjects:	Original Paper
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3569989/ https://ncbi.nlm.nih.gov/pubmed/23197296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.145
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RNF4 is required for DNA double-strand break repair in vivo

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