RNF4 is required for DNA double-strand break repair in vivo

Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signaling and repair proteins to the sites of DNA lesions. Coordinated protein SUMOylation and ubiquitylation have crucial...

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Main Authors: Vyas, R, Kumar, R, Clermont, F, Helfricht, A, Kalev, P, Sotiropoulou, P, Hendriks, I A, Radaelli, E, Hochepied, T, Blanpain, C, Sablina, A, van Attikum, H, Olsen, J V, Jochemsen, A G, Vertegaal, A C O, Marine, J-C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569989/
https://ncbi.nlm.nih.gov/pubmed/23197296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.145
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