Genetic and biophysical studies of diphtheria toxin repressor (DtxR) and the hyperactive mutant DtxR(E175K) support a multistep model of activation

The diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae is the prototypic member of a superfamily of transition metal ion-activated transcriptional regulators that have been isolated from Gram-positive prokaryotes. Upon binding divalent transition metal ions, the N-terminal domain of...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Love, John F., vanderSpek, Johanna C., Marin, Vedrana, Guerrero, Luis, Logan, Timothy M., Murphy, John R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC356980/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14983039/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0303794101
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