IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium

Acute injury to the intestinal mucosa is a major dose-limiting complication of abdominal radiation therapy. We studied the role of the transcription factor NF-κB in protection against radiation-induced apoptosis in the intestinal epithelium in vivo. We use mice in which NF-κB signaling through IκB-k...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Egan, Laurence J., Eckmann, Lars, Greten, Florian R., Chae, Sungwon, Li, Zhi-Wei, Myhre, Gennett M., Robine, Sylvie, Karin, Michael, Kagnoff, Martin F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2004
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC356971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14983030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0306734101
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