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Studying Ligand Efficacy at G Protein-Coupled Receptors Using FRET
Drug “ligands” that bind G protein-coupled receptors (GPCRs) can either stimulate, fully (full agonists) or partially (partial agonists), or reduce (inverse agonists) basal receptor activity, by stabilizing different receptor conformations. The term “intrinsic efficacy” was introduced as a parameter...
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| Formato: | Artigo |
| Idioma: | Inglês |
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2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568766/ https://ncbi.nlm.nih.gov/pubmed/21870223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-61779-160-4_6 |
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