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The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression

Parathyroid hormone (PTH) is currently the only approved anabolic agent for osteoporosis pharmacotherapy in the USA. However, the molecular and cellular mechanisms underlying which intermittent PTH stimulates bone formation are not fully established. Activating transcription factor 4 (ATF4) was rece...

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Main Authors: Fei, Yurong, Xiao, Liping, Hurley, Marja M.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568701/
https://ncbi.nlm.nih.gov/pubmed/21806973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.07.066
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