Engineering a BCR-ABL–activated caspase for the selective elimination of leukemic cells

Increased understanding of the precise molecular mechanisms involved in cell survival and cell death signaling pathways offers the promise of harnessing these molecules to eliminate cancer cells without damaging normal cells. Tyrosine kinase oncoproteins promote the genesis of leukemias through both...

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Detalhes bibliográficos
Main Authors: Kurokawa, Manabu, Ito, Takahiro, Yang, Chih-Sheng, Zhao, Chen, Macintyre, Andrew N., Rizzieri, David A., Rathmell, Jeffrey C., Deininger, Michael W., Reya, Tannishtha, Kornbluth, Sally
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568344/
https://ncbi.nlm.nih.gov/pubmed/23324740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206551110
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