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Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration

HIV-1 reverse transcriptase discriminates poorly between dUTP and dTTP, and accordingly, viral DNA products become heavily uracilated when viruses infect host cells that contain high ratios of dUTP:dTTP. Uracilation of invading retroviral DNA is thought to be an innate immunity barrier to retroviral...

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Detalhes bibliográficos
Main Authors: Weil, Amy F., Ghosh, Devlina, Zhou, Yan, Seiple, Lauren, McMahon, Moira A., Spivak, Adam M., Siliciano, Robert F., Stivers, James T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568341/
https://ncbi.nlm.nih.gov/pubmed/23341616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219702110
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