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Effect of cryoprotectants on the porosity and stability of insulin-loaded PLGA nanoparticles after freeze-drying

PLGA nanoparticles are useful to protect and deliver proteins in a localized or targeted manner, with a long-term systemic delivery pattern intended to last for a period of time, depending on polymer bioerosion and biodegradability. However, the principal concern regarding these carriers is the hydr...

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Autors principals: Fonte, Pedro, Soares, Sandra, Costa, Ana, Andrade, José Carlos, Seabra, Vítor, Reis, Salette, Sarmento, Bruno
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568117/
https://ncbi.nlm.nih.gov/pubmed/23507897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/biom.23246
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