Ozagrel hydrochloride, a selective thromboxane A(2) synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice

BACKGROUND: Overdosed acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) causes severe liver injury. We examined the effects of ozagrel, a selective thromboxane A(2) (TXA(2)) synthase inhibitor, on liver injury induced by APAP overdose in mice. METHODS: Hepatotoxicity was induced to ICR male...

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Detalhes bibliográficos
Main Authors: Tomishima, Yoshiro, Ishitsuka, Yoichi, Matsunaga, Naoya, Nagatome, Minako, Furusho, Hirokazu, Irikura, Mitsuru, Ohdo, Shigehiro, Irie, Tetsumi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568068/
https://ncbi.nlm.nih.gov/pubmed/23363429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-13-21
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