A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population

Homocysteine is an independent risk factor for various cardiovascular diseases. There are two ways to remove homocysteine from embryonic cardiac cells: remethylation to form methionine or transsulfuration to form cysteine. Cystathionine β-synthase (CBS) catalyzes the first step of homocysteine trans...

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Main Authors: Zhao, Jian-Yuan, Yang, Xue-Yan, Shi, Kai-Hu, Sun, Shu-Na, Hou, Jia, Ye, Zhi-Zhou, Wang, Jue, Duan, Wen-Yuan, Qiao, Bin, Chen, Yi-Jiang, Shen, Hong-Bing, Huang, Guo-Ying, Jin, Li, Wang, Hong-Yan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567826/
https://ncbi.nlm.nih.gov/pubmed/22986502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.135
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