Phosphatidylethanolamine Deficiency in Mammalian Mitochondria Impairs Oxidative Phosphorylation and Alters Mitochondrial Morphology

Mitochondrial dysfunction is implicated in neurodegenerative, cardiovascular, and metabolic disorders, but the role of phospholipids, particularly the nonbilayer-forming lipid phosphatidylethanolamine (PE), in mitochondrial function is poorly understood. Elimination of mitochondrial PE (mtPE) synthe...

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Main Authors: Tasseva, Guergana, Bai, Helin Daniel, Davidescu, Magdalena, Haromy, Alois, Michelakis, Evangelos, Vance, Jean E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Lipids
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567666/
https://ncbi.nlm.nih.gov/pubmed/23250747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434183
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