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Metabolomics Implicates Altered Sphingolipids in Chronic Pain of Neuropathic Origin

Neuropathic pain is a debilitating condition for which the development of effective treatments has been limited by an incomplete understanding of its chemical basis. We show by using untargeted metabolomics that sphingomyelin-ceramide metabolism is altered in the dorsal horn of rats with neuropathic...

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Main Authors: Patti, Gary J., Yanes, Oscar, Shriver, Leah, Courade, Jean-Phillipe, Tautenhahn, Ralf, Manchester, Marianne, Siuzdak, Gary
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567618/
https://ncbi.nlm.nih.gov/pubmed/22267119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.767
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