Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

Obesity develops due to altered energy homeostasis favoring fat storage. Here we describe a novel transcription co-regulator for adiposity and energy metabolism, TRIP-Br2 (also called SERTAD2). TRIP-Br2 null mice are resistant to obesity and obesity-related insulin resistance. Adipocytes of the knoc...

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Détails bibliographiques
Auteurs principaux: Liew, Chong Wee, Boucher, Jeremie, Cheong, Jit Kong, Vernochet, Cecile, Koh, Ho-Jin, Mallol, Cristina, Townsend, Kristy, Langin, Dominique, Kawamori, Dan, Hu, Jiang, Tseng, Yu-Hua, Hellerstein, Marc K, Farmer, Stephen R, Goodyear, Laurie, Doria, Alessandro, Blüher, Matthias, Hsu, Stephen I-Hong, Kulkarni, Rohit N
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567215/
https://ncbi.nlm.nih.gov/pubmed/23291629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3056
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