Silencing Mutated β-Catenin Inhibits Cell Proliferation and Stimulates Apoptosis in the Adrenocortical Cancer Cell Line H295R

CONTEXT: Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the Wnt/β-catenin signaling pathway seem...

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Main Authors: Gaujoux, Sébastien, Hantel, Constanze, Launay, Pierre, Bonnet, Stéphane, Perlemoine, Karine, Lefèvre, Lucile, Guillaud-Bataille, Marine, Beuschlein, Felix, Tissier, Frédérique, Bertherat, Jérôme, Rizk-Rabin, Marthe, Ragazzon, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567123/
https://ncbi.nlm.nih.gov/pubmed/23409032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055743
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