Molecular Mechanisms Underlying the Analgesic Property of Intrathecal Dexmedetomidine and Its Neurotoxicity Evaluation: An In Vivo and In Vitro Experimental Study

BACKGROUND: Dexmedetomidine (DEX) has been used under perioperative settings as an adjuvant to enhance the analgesic property of local anesthetics by some anesthesiologists. However, the analgesic mechanisms and neurotoxicity of DEX were poorly understood. This study examined the effect of DEX alone...

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Detalhes bibliográficos
Main Authors: Zhang, Hongxing, Zhou, Fang, Li, Chen, Kong, Min, Liu, He, Zhang, Peng, Zhang, Song, Cao, Junli, Zhang, Licai, Ma, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567091/
https://ncbi.nlm.nih.gov/pubmed/23409000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055556
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