Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum

BACKGROUND: CD72 is an inhibitory co-receptor expressed on B cells. We previously demonstrated significant association of the polymorphism of the CD72 gene with susceptibility to human systemic lupus erythematosus (SLE) in individuals carrying a SLE-susceptible FCGR2B genotype (FCGR2B-232Thr/Thr). T...

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Bibliographic Details
Main Authors: Hitomi, Yuki, Adachi, Takahiro, Tsuchiya, Naoyuki, Honda, Zen-Ichiro, Tokunaga, Katsushi, Tsubata, Takeshi
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565990/
https://ncbi.nlm.nih.gov/pubmed/23268649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-13-72
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