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Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells

BACKGROUND: p53 is the most frequently mutated tumor-suppressor gene in human cancers. It has been reported that mutations in p53 result not only in the loss of its ability as a tumor suppressor, but also in the gain of novel cancer-related functions that contribute to oncogenesis. The present study...

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Main Authors: Zhu, Hai-Bin, Yang, Kai, Xie, Yan-Qi, Lin, Yi-Wei, Mao, Qi-Qi, Xie, Li-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565885/
https://ncbi.nlm.nih.gov/pubmed/23356234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-7819-11-22
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