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On the dynamics of neutral mutations in a mathematical model for a homogeneous stem cell population
The theory of the clonal origin of cancer states that a tumour arises from one cell that acquires mutation(s) leading to the malignant phenotype. It is the current belief that many of these mutations give a fitness advantage to the mutant population allowing it to expand, eventually leading to disea...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Royal Society
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3565697/ https://ncbi.nlm.nih.gov/pubmed/23221988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2012.0810 |
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