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Mitochondrial dysfunction and oxidative stress in Parkinson’s disease and monogenic parkinsonism
The pathogenic mechanisms that underlie Parkinson’s disease remain unknown. Here, we review evidence from both sporadic and genetic forms of Parkinson’s disease that implicate both mitochondria and oxidative stress as central players in disease pathogenesis. A systemic deficiency in complex I of the...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3565564/ https://ncbi.nlm.nih.gov/pubmed/23064436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.10.011 |
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