Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1

Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme branching from glycolysis in the three-step serine biosynthetic pathway. Recent evidence has shown that PHGDH is amplified in human breast cancer and melanoma and plays a key role in cancer metabolism. However, PHGDH expression in glioma and...

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Bibliographic Details
Main Authors: Liu, Jinlong, Guo, Shaolei, Li, Qingzhi, Yang, Lixuan, Xia, Zhibai, Zhang, Longjuan, Huang, Zhengsong, Zhang, Nu
Format: Artigo
Language:Inglês
Published: Springer US 2012
Subjects:
Laboratory Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565087/
https://ncbi.nlm.nih.gov/pubmed/23229761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-012-1018-x
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