In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4

1. Women who experience hot flashes as a side effect of tamoxifen therapy often try botanical remedies such as black cohosh to alleviate these symptoms. Since pharmacological activity of tamoxifen is dependent on the metabolic conversion into active metabolites by the action of cytochromes P450 2D6...

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Autores principales: Li, Jinghu, Gödecke, Tanja, Chen, Shao-Nong, Imai, Ayano, Lankin, David, Farnsworth, Norman R., Pauli, Guido F., van Breemen, Richard B., Nikolić, Dejan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565011/
https://ncbi.nlm.nih.gov/pubmed/21827327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2011.603385
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