In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population

BACKGROUND: The selection pressure imposed by the parasite has a functional consequence on the immune genes, leading to altered immune function in which regulatory T cells (Tregs) induced by parasites during infectious challenges modulate or thwart T effector cell mechanism. METHODS: We identified a...

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Main Authors: Huang, Xiangsheng, Kühne, Vera, Kun, Jürgen F J, Soboslay, Peter T, Lell, Bertrand, TP, Velavan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564939/
https://ncbi.nlm.nih.gov/pubmed/23217119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-13-117
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