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In vivo SELEX for Identification of Brain-penetrating Aptamers

The physiological barriers of the brain impair drug delivery for treatment of many neurological disorders. One delivery approach that has not been investigated for their ability to penetrate the brain is RNA-based aptamers. These molecules can impart delivery to peripheral tissues and circulating im...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cheng, Congsheng, Chen, Yong Hong, Lennox, Kim A, Behlke, Mark A, Davidson, Beverly L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564417/
https://ncbi.nlm.nih.gov/pubmed/23299833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.59
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