Over-expression of IGF1R and Frequent Mutational Inactivation of SDHA in Wild-type SDHB-negative Gastrointestinal Stromal Tumors

Approximately 15% of gastrointestinal stromal tumors (GISTs) in adults and 85% in children lack mutations in KIT and PDGFRA and are known as wild type GISTs. Wild type GISTs from adults and children express high levels of insulin-like growth factor 1 receptor (IGF1R) and exhibit stable genomes compa...

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Bibliographic Details
Main Authors: Belinsky, Martin G., Rink, Lori, Flieder, Douglas B., Jahromi, Mona S., Schiffman, Joshua D., Godwin, Andrew K., von Mehren, Margaret
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564228/
https://ncbi.nlm.nih.gov/pubmed/23109135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22023
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