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IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells()
After undergoing Ig somatic hypermutation and antigen selection, germinal center (GC) B cells terminally differentiate into either memory or plasma cells (PCs). It is known that the CD40L and IL-21/STAT3 signaling pathways play critical roles in this process, yet it is unclear how the B cell transcr...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563840/ https://ncbi.nlm.nih.gov/pubmed/23325890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201678 |
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