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The Prolyl Isomerase Pin1 Acts Synergistically with CDK2 to Regulate the Basal Activity of Estrogen Receptor α in Breast Cancer

In hormone receptor-positive breast cancers, most tumors in the early stages of development depend on the activity of the estrogen receptor and its ligand, estradiol. Anti-estrogens, such as tamoxifen, have been used as the first line of therapy for over three decades due to the fact that they elici...

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Autori principali: Lucchetti, Chiara, Caligiuri, Isabella, Toffoli, Giuseppe, Giordano, Antonio, Rizzolio, Flavio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563590/
https://ncbi.nlm.nih.gov/pubmed/23390529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055355
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