Sequence Heterogeneity in Closed Simian Virus 40 Deoxyribonucleic Acid

The heteroduplex molecules formed by self-annealing of denatured, singly nicked simian virus 40 (SV40) deoxyribonucleic acid (DNA) prepared from closed viral DNA were examined by formamide-protein film electron microscopy to test the DNA for sequence homogeneity. Sequence inhomogeneity appears in th...

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Bibliographic Details
Main Authors: Tai, Henry T., Smith, Charles Allen, Sharp, Phillip A., Vinograd, Jerome
Format: Artigo
Language:Inglês
Published: 1972
Subjects:
Animal Viruses
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC356299/
https://ncbi.nlm.nih.gov/pubmed/4335521
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