Chitosan is a surprising negative modulator of cytotoxic CD8(+) T cell responses elicited by adenovirus cancer vaccines

Adjuvants modulate protective CD8(+) T cell responses generated by cancer vaccines. We have previously shown that immunostimulatory CpG ODN significantly augments tumor protection in mice given adenovirus cancer vaccines. Here, we examined the impact of chitosan, another candidate vaccine adjuvant,...

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Hlavní autoři: Lemke, Caitlin D., Graham, Jessica B., Geary, Sean M., Zamba, Gideon, Lubaroff, David M., Salem, Aliasger K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562499/
https://ncbi.nlm.nih.gov/pubmed/21780831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100464y
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