Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of...

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Autors principals: Zhang, Yong-Hong, Zhao, Yan, Li, Ning, Peng, Yan-Chun, Giannoulatou, Eleni, Jin, Rong-Hua, Yan, Hui-Ping, Wu, Hao, Liu, Jin-Hua, Liu, Ning, Wang, Da-Yan, Shu, Yue-Long, Ho, Ling-Pei, Kellam, Paul, McMichael, Andrew, Dong, Tao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562464/
https://ncbi.nlm.nih.gov/pubmed/23361009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2433
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