An Adenovirus Vector Incorporating Carbohydrate Binding Domains Utilizes Glycans for Gene Transfer

BACKGROUND: Vectors based on human adenovirus serotype 5 (HAdV-5) continue to show promise as delivery vehicles for cancer gene therapy. Nevertheless, it has become clear that therapeutic benefit is directly linked to tumor-specific vector localization, highlighting the need for tumor-targeted gene...

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Main Authors: Kim, Julius W., Glasgow, Joel N., Nakayama, Masaharu, Ak, Ferhat, Ugai, Hideyo, Curiel, David T.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562239/
https://ncbi.nlm.nih.gov/pubmed/23383334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055533
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