The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells

LSH, a protein related to the SNF2 family of chromatin-remodelling ATPases, is essential for the correct establishment of DNA methylation levels and patterns in plants and mammalian cells. However, some of the phenotypes resulting from LSH deficiency cannot be explained easily by defects in DNA meth...

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Bibliographic Details
Main Authors: Burrage, Joe, Termanis, Ausma, Geissner, Andreas, Myant, Kevin, Gordon, Katrina, Stancheva, Irina
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561860/
https://ncbi.nlm.nih.gov/pubmed/22946062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.111252
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