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The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells

LSH, a protein related to the SNF2 family of chromatin-remodelling ATPases, is essential for the correct establishment of DNA methylation levels and patterns in plants and mammalian cells. However, some of the phenotypes resulting from LSH deficiency cannot be explained easily by defects in DNA meth...

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Detalhes bibliográficos
Main Authors: Burrage, Joe, Termanis, Ausma, Geissner, Andreas, Myant, Kevin, Gordon, Katrina, Stancheva, Irina
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561860/
https://ncbi.nlm.nih.gov/pubmed/22946062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.111252
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