Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis

Topical application of coal tar is one of the oldest therapies for atopic dermatitis (AD), a T helper 2 (Th2) lymphocyte–mediated skin disease associated with loss-of-function mutations in the skin barrier gene, filaggrin (FLG). Despite its longstanding clinical use and efficacy, the molecular mecha...

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Main Authors: van den Bogaard, Ellen H., Bergboer, Judith G.M., Vonk-Bergers, Mieke, van Vlijmen-Willems, Ivonne M.J.J., Hato, Stanleyson V., van der Valk, Pieter G.M., Schröder, Jens Michael, Joosten, Irma, Zeeuwen, Patrick L.J.M., Schalkwijk, Joost
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561798/
https://ncbi.nlm.nih.gov/pubmed/23348739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65642
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