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Manipulating Cofactor Binding Thermodynamics in an Artificial Oxygen Transport Protein
We report the mutational analysis of an artificial oxygen transport protein, HP-7, which operates via a mechanism akin to human neuroglobin and cytoglobin. This protein destabilizes one of two heme-ligating histidine residues by coupling histidine side chain ligation with the burial of three charged...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561710/ https://ncbi.nlm.nih.gov/pubmed/22004125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201242a |
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