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Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
Cellular senescence both protects multicellular organisms from cancer and contributes to their aging(1). The preeminent tumor suppressor p53 plays an important role in the induction and maintenance of senescence, but how p53 carries out this function remains poorly understood(1–3). Additionally, whi...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561500/ https://ncbi.nlm.nih.gov/pubmed/23334421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11776 |
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