Class II HDAC Inhibition Hampers Hepatic Stellate Cell Activation by Induction of MicroRNA-29

BACKGROUND: The conversion of a quiescent vitamin A storing hepatic stellate cell (HSC) to a matrix producing, contractile myofibroblast-like activated HSC is a key event in the onset of liver disease following injury of any aetiology. Previous studies have shown that class I histone deacetylases (H...

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Main Authors: Mannaerts, Inge, Eysackers, Nathalie, Onyema, Oscar O., Van Beneden, Katrien, Valente, Sergio, Mai, Antonello, Odenthal, Margarete, van Grunsven, Leo A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561334/
https://ncbi.nlm.nih.gov/pubmed/23383282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055786
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