TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4(+) T cells across the virological synapse

BACKGROUND: Dendritic cells and their subsets, located at mucosal surfaces, are among the first immune cells to encounter disseminating pathogens. The cellular restriction factor BST-2/tetherin (also known as CD317 or HM1.24) potently restricts HIV-1 release by retaining viral particles at the cell...

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Bibliographic Details
Main Authors:	Blanchet, Fabien P, Stalder, Romaine, Czubala, Magdalena, Lehmann, Martin, Rio, Laura, Mangeat, Bastien, Piguet, Vincent
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2013
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3561259/ https://ncbi.nlm.nih.gov/pubmed/23311681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-6
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TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4(+) T cells across the virological synapse

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