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Trypanosoma cruzi Response to Sterol Biosynthesis Inhibitors: Morphophysiological Alterations Leading to Cell Death

The protozoan parasite Trypanosoma cruzi displays similarities to fungi in terms of its sterol lipid biosynthesis, as ergosterol and other 24-alkylated sterols are its principal endogenous sterols. The sterol pathway is thus a potential drug target for the treatment of Chagas disease. We describe he...

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Hlavní autoři: Kessler, Rafael Luis, Soares, Maurilio José, Probst, Christian Macagnan, Krieger, Marco Aurélio
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561218/
https://ncbi.nlm.nih.gov/pubmed/23383204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055497
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