T Lymphocytes from Chagasic Patients Are Activated but Lack Proliferative Capacity and Down-Regulate CD28 and CD3ζ

BACKGROUND: Chronic persistent infections have been associated with T lymphocytes functional impairment. The aim of this study was to compare the activation status, the proliferative potential and the expression of CD28 and CD3ζ chain on T lymphocytes between chronic chagasic patients and uninfected...

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Main Authors: Giraldo, Nicolás A., Bolaños, Natalia I., Cuellar, Adriana, Roa, Nubia, Cucunubá, Zulma, Rosas, Fernando, Velasco, Víctor, Puerta, Concepción J., González, John M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561132/
https://ncbi.nlm.nih.gov/pubmed/23383358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002038
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