Inhibition of p38 MAPK diminishes doxorubicin-induced drug resistance associated with P-glycoprotein in human leukemia K562 cells

BACKGROUND: Several studies have shown that multidrug transporters, such as P-glycoprotein (PGP), are involved in cell resistance to chemotherapy and refractory epilepsy. The p38 mitogen-activated protein kinase (MAPK) signaling pathway may increase PGP activity. However, p38-mediated drug resistanc...

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Bibliografiske detaljer
Main Authors: Chen, Yinghui, Zhao, Yongbo, Wang, Cuicui, Xiao, Xia, Zhou, Xiaoyong, Xu, Guoxiong
Format: Artigo
Sprog:Inglês
Udgivet: International Scientific Literature, Inc. 2012
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560559/
https://ncbi.nlm.nih.gov/pubmed/23018344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.883477
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