Optimization of a high-throughput whole blood expression profiling methodology and its application to assess the pharmacodynamics of interferon (IFN) beta-1a or polyethylene glycol-conjugated IFN beta-1a in healthy clinical trial subjects

BACKGROUND: Clinical trials offer a unique opportunity to study human disease and response to therapy in a highly controlled setting. The application of high-throughput expression profiling to peripheral blood from clinical trial subjects could facilitate the identification of transcripts that funct...

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Hauptverfasser: Allaire, Normand E, Bushnell, Steven E, Bienkowska, Jadwiga, Brock, Graham, Carulli, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560109/
https://ncbi.nlm.nih.gov/pubmed/23289891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-6-8
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