Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction

Interspecies differences in drug metabolism have made it difficult to use preclinical animal testing data to predict the drug metabolites or potential drug-drug interactions (DDIs) that will occur in humans. Although chimeric mice with humanized livers can produce known human metabolites for test su...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Nishimura, Toshiko, Hu, Yajing, Wu, Manhong, Pham, Edward, Suemizu, Hiroshi, Elazar, Menashe, Liu, Michael, Idilman, Ramazan, Yurdaydin, Cihan, Angus, Peter, Stedman, Catherine, Murphy, Brian, Glenn, Jeffrey, Nakamura, Masato, Nomura, Tatsuji, Chen, Yuan, Zheng, Ming, Fitch, William L., Peltz, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558826/
https://ncbi.nlm.nih.gov/pubmed/23143674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198697
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados