Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms

Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons. Epileptiform bursts with an underlying plateau potential in neurons are a cellular correlate of seizures. Emerging evidence suggests that the plateau potential is mediated by neuronal canoni...

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Autors principals: Phelan, Kevin D., Shwe, U Thaung, Abramowitz, Joel, Wu, Hong, Rhee, Sung W., Howell, Matthew D., Gottschall, Paul E., Freichel, Marc, Flockerzi, Veit, Birnbaumer, Lutz, Zheng, Fang
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558807/
https://ncbi.nlm.nih.gov/pubmed/23188715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.082271
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