Transforming Growth Factor β-Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

Smad proteins are the most well-characterized intracellular effectors of the transforming growth factor β (TGF-β) signal. The ability of the Smads to act as transcriptional activators via TGF-β-induced recruitment to Smad binding elements (SBE) within the promoters of TGF-β target genes has been fir...

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Bibliographic Details
Main Authors: Frederick, Joshua P., Liberati, Nicole T., Waddell, David S., Shi, Yigong, Wang, Xiao-Fan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC355825/
https://ncbi.nlm.nih.gov/pubmed/14993291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.6.2546-2559.2004
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